Supervillin binds the Rac/Rho-GEF Trio and increases Trio-mediated Rac1 activation
نویسندگان
چکیده
منابع مشابه
M-cadherin activates Rac1 GTPase through the Rho-GEF trio during myoblast fusion.
Cadherins are transmembrane glycoproteins that mediate Ca(2+)-dependent homophilic cell-cell adhesion and play crucial role during skeletal myogenesis. M-cadherin is required for myoblast fusion into myotubes, but its mechanisms of action remain unknown. The goal of this study was to cast some light on the nature of the M-cadherin-mediated signals involved in myoblast fusion into myotubes. We f...
متن کاملM-Cadherin Activates Rac1 GTPase through the Rho-GEF Trio during Myoblast Fusion□D □V
Cadherins are transmembrane glycoproteins that mediate Ca2 -dependent homophilic cell–cell adhesion and play crucial role during skeletal myogenesis. M-cadherin is required for myoblast fusion into myotubes, but its mechanisms of action remain unknown. The goal of this study was to cast some light on the nature of the M-cadherin–mediated signals involved in myoblast fusion into myotubes. We fou...
متن کاملIdentification of a mitotic Rac-GEF, Trio, that counteracts MgcRacGAP function during cytokinesis
The Rho GTPases RhoA and Rac1 function as master regulators of cytokinesis by controlling the actomyosin cytoskeleton. RhoA and Rac1 have to be respectively activated and inactivated at the division plane for cytokinesis to occur properly. The inactivation of Rac1 at the cleavage furrow is controlled by MgcRacGAP. However, the guanine-nucleotide exchange factor (GEF) that activates Rac1 during ...
متن کاملTrio mediates netrin-1-induced Rac1 activation in axon outgrowth and guidance.
The chemotropic guidance cue netrin-1 promotes neurite outgrowth through its receptor Deleted in Colorectal Cancer (DCC) via activation of Rac1. The guanine nucleotide exchange factor (GEF) linking netrin-1/DCC to Rac1 activation has not yet been identified. Here, we show that the RhoGEF Trio mediates Rac1 activation in netrin-1 signaling. We found that Trio interacts with the netrin-1 receptor...
متن کاملPackage ‘ trio ’
Description Testing SNPs and SNP interactions with a genotypic TDT. This package furthermore contains functions for computing pairwise values of LD measures and for identifying LD blocks, as well as functions for setting up matched case pseudo-control genotype data for case-parent trios in order to run trio logic regression, for imputing missing genotypes in trios, for simulating case-parent tr...
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ژورنال
عنوان ژورنال: Cytoskeleton
سال: 2015
ISSN: 1949-3584
DOI: 10.1002/cm.21210